toxin A injections

  Definition   Medications  

 algorithm for

  Prevalence   Systemic treatment    
  Impact on quality of life   Topical treatment     Axillary and inguinal HH  

    for armpits

 >     VIDEO
  Classification   The gel Advantage     Palmoplantar HH  

    for hands

 >     VIDEO
  The Control of sweating   Needle Free Injections     Craniofacial HH  

    for feet

 >     VIDEO
Topical Treatment of HH : preparations containing aluminum chloride

Antiperspirants and deodorants :

The aim of an antiperspirant is to decrease the amount of sweating by creating a plug in the acrosyringium. The plug is made of aluminum salts.

Deodorants, on the other hand are products aimed at decreasing the odor with an antibacterial agent or masking it with a perfume.

Topical anticholinergic medications:

Topical glycopyrrolate as 0.5% aqueous solution has been reported also to control HH of the forehead.

Aluminum chlorhydrate:

Present in most antiperspirants available over the counter. Its concentration is higher in antiperspirants than in deodorants. Among the aluminum salts, aluminum chloride is the most effective followed by aluminum chlorhydrate / zinc compounds and finally aluminum chlorhydrate used alone.

Aluminum chloride hexahydrate in an alcoholic solution:

Aluminum chloride hexahydrate is available as a 20% alcoholic solution Drysol® and at 6% concentration under the name Xerac ac®.  Aluminum chloride hexahydrate has to be used in a distinctive way. The armpits, hands and feet must be thoroughly washed and blow dried before its application. The solution is applied under occlusion with Cellophane paper in resistant cases. Gloves may be used for the hands and plastic bags for the feet. Occlusion is kept overnight. This procedure is repeated 2 to 3 nights per week. Irritation is a common side effect. Stinging and burning sensation are common at the beginning but may subside after a while.

Aluminum Chloride Hexahydrate in a salicylic acid gel base:

IIn 1978, Aluminum Chloride Hexahydrate in a salicylic acid gel base was first used in a middle aged woman suffering from axillary HH on the verge of getting a surgery to get rid of her axillary glands after failing to respond to Drysol under occlusion. The outcome was impressive.  Her surgery has been cancelled and over a 100 similar cases were referred to me during that same year. A similar extemporaneous formulation of 15% aluminum chloride in a salicylic acid gel could now be obtained without a prescription at any pharmacy in Canada Hydrosal®

The extemporaneous formulation of 35% Aluminum chloride in a Salicylic Acid Gel for the treatment of palmar &/or plantar hyperhidrosis could be prepared as follows:

Ingredients   Weight Compounding steps
Aluminum Chloride hexahydrate 15.4g Grind 15.4 grams of aluminum chloride hexahydrate in a mortar until a fine powder is obtained.
Hydrosal® used as a vehicle (already containing 7.5g of AlCl3) 50g Add the former slowly (i.e. over a 10 minutes period) to the hydrosal gel, and mix using an electric agitator. This compounding will give us 65.4g of gel having 35% w/w of AlCl3.
Keep this formulation refrigeratedr.

Systemic Treatment of HH >>


Created and financed by Antranik Benohanian MD, FRCPC -  copyright © 2000
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